The prize: ending the Apocalypse. The price: Sam's life. Season 5's horrific finale left Dean alone, as Sam descended into Hell. Now a different man, Dean vows to stop hunting and devote himself to building a family with Lisa and her son Ben. Then, mysteriously, Sam reappears, drawing Dean back into the old life. But Sam's a different man too. He's returned without his soul. How the Winchesters confront this greatest challenge yet to their powerful bond is the troubled heart - and soul - of the profound and thrilling 5-Disc, 22-Episode Season 6. As the brothers struggle to reunite, they must also battle deadly supernatural forces. Demons. Angels. Vampires. Shapeshifters. And a terrifying new foe called the Mother of All.
- Jensen Ackles: A Director's Journey featurette
- Supernatural and the Quest for the Soul featurette
- "All Hell Breaks Loose" Parts 1 & 2: Bonus Episodes from Supernatural: The Anime Series
- Audio Commentary on "Clap Your Hands if you Believe" with EPs Robert Singer, Sera Gamble, and Ben Edlund
- Audio Commentary on "The French Mistake" with EP's Robert Singer, Sera Gamble and Ben Edlund.
- "The French Mistake" Alternate Takes and Outtakes Gag Reel
- Blu-ray Exclusive: The Hunter's Guide to Season Six featurette
- Blu-ray Exclusive: Selectable The French Mistake Trivia Track