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Analysis and comments on Insomniac by Sylvia Plath

Comment 6 of 6, added on May 26th, 2013 at 8:14 AM.
Alaska volcano shoots huge ash plumes into the air - USA Today lkg

The U.S. Food and Drug Administration today approved Xofigo (radium Ra 223
dichloride) to treat men with symptomatic late-stage (metastatic)
castration-resistant prostate cancer that has spread to bones but not to
other organs. It is intended for men whose cancer has spread after
receiving medical or surgical therapy to lower testosterone.

Prostate cancer forms in a gland in the male reproductive system found
below the bladder and in front of the rectum. The male sex hormone
testosterone stimulates the prostate tumors to grow. According to the
National Cancer Institute, an estimated 238,590 men will be diagnosed with
prostate cancer and 29,720 will die from the disease in 2013.

Xofigo is being approved more than three months ahead of the product¡¯s
prescription drug user fee goal date of Aug. 14, 2013, the date the agency
was scheduled to complete review of the drug application. The FDA reviewed
Xofigo under the agency¡¯s priority review program, which provides for an
expedited review of drugs that appear to provide safe and effective therapy
when no satisfactory alternative therapy exists, or offer significant
improvement compared to marketed products.

¡°Xofigo binds with minerals in the bone to deliver radiation directly to
bone tumors, limiting the damage to the surrounding normal tissues,¡± said
Richard Pazdur, M.D., director of the Office of Hematology and Oncology
Products in the FDA¡¯s Center for Drug Evaluation and Research. ¡°Xofigo is
the second prostate cancer drug approved by the FDA in the past year that
demonstrates an ability to extend the survival of men with metastatic
prostate cancer.¡±

In August 2012, the FDA approved Xtandi to treat men with metastatic
castration-resistant prostate cancer that has spread or recurred, even with
medical or surgical therapy to minimize testosterone. Xtandi is approved
for patients who have previously been treated the chemotherapy drug
docetaxel.

Xofigo¡¯s safety and effectiveness were evaluated in a single clinical
trial of 809 men with symptomatic castration-resistant prostate cancer that
spread to bones but not to other organs. Patients were randomly assigned to
receive Xofigo or a placebo plus best standard of care.

The study was designed to measure overall survival. Results from a
pre-planned interim analysis showed men receiving Xofigo lived a median of
14 months compared to a median of 11.2 months for men receiving placebo. An
exploratory updated analysis conducted later in the trial confirmed
Xofigo¡¯s ability to extend overall survival.

The most common side effects reported during clinical trials in men
receiving Xofigo were nausea, diarrhea, vomiting and swelling of the leg,
ankle or foot. The most common abnormalities detected during blood testing
included low levels of red blood cells (anemia), lymphocytes
(lymphocytopenia), white blood cells (leukopenia), platelets
(thrombocytopenia) and infection-fighting white blood cells (neutropenia).




gandigoBligma from Uganda
Comment 5 of 6, added on August 9th, 2012 at 5:37 AM.
JSGLoPSCKED

Nice blogpost, esailepcly since it matches your mysterious avatar: secrecy
marketing meets personal branding Poetry bombing reminds me of a message I
once found in my Scotch & Soda pants. To Whoever Finds This: you have the
following choices 1. leave it where you found it for someone else to find
it, 2. write a note with date and where you found it, and drop it in the
mailbox, 3. give it to someone else, 4. enjoy it and have a good day. It
was stitched somewhere inside.

Arm from Canada
Comment 4 of 6, added on December 16th, 2010 at 12:00 AM.
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daily jobs news
Comment 3 of 6, added on January 13th, 2007 at 1:35 PM.

Insomniac is my favourite poem by Sylvia Plath. I particularly like the
stanza about the pills. And the beginning of the next one

His head is a little interior of grey mirrors.
Each gesture flees immediately down an alley
Of diminishing perspectives, and its significance
Drains like water out the hole at the far end.

That is amazingly well put. I've suffered insomnia since my teens (I'm 34
now). I can vouch she definitely knows what she is talking about.

Gledwood

Gledwood from United Kingdom
Comment 2 of 6, added on November 4th, 2005 at 3:49 AM.

the poem truly speaks of how restless and torturous sleeplessness is. The
confusion affects the person both physically and pyshologically. The way
she depicts the man's pain lets us into the world of a person suffering
from this disease.

charleen from Singapore
Comment 1 of 6, added on August 4th, 2005 at 4:14 PM.

The end of the poem is particularly haunting because it refers to everyone
in the city as being brainwashed, or suffering from the addling disease of
insomnia. The thought of everyone walking around half-dead, half-asleep, is
altogether a creepy image.

Taylor from United States

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Information about Insomniac

Poet: Sylvia Plath
Poem: Insomniac
Volume: The Collected Poems
Year: 1961
Added: Feb 20 2003
Viewed: 2963 times


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