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Analysis and comments on The Demiurge's Laugh by Robert Frost

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Comment 8 of 28, added on September 6th, 2013 at 10:27 PM.
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Comment 7 of 28, added on May 26th, 2013 at 9:25 AM.
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The U.S. Food and Drug Administration today approved Xofigo (radium Ra 223
dichloride) to treat men with symptomatic late-stage (metastatic)
castration-resistant prostate cancer that has spread to bones but not to
other organs. It is intended for men whose cancer has spread after
receiving medical or surgical therapy to lower testosterone.

Prostate cancer forms in a gland in the male reproductive system found
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testosterone stimulates the prostate tumors to grow. According to the
National Cancer Institute, an estimated 238,590 men will be diagnosed with
prostate cancer and 29,720 will die from the disease in 2013.

Xofigo is being approved more than three months ahead of the product¡¯s
prescription drug user fee goal date of Aug. 14, 2013, the date the agency
was scheduled to complete review of the drug application. The FDA reviewed
Xofigo under the agency¡¯s priority review program, which provides for an
expedited review of drugs that appear to provide safe and effective therapy
when no satisfactory alternative therapy exists, or offer significant
improvement compared to marketed products.

¡°Xofigo binds with minerals in the bone to deliver radiation directly to
bone tumors, limiting the damage to the surrounding normal tissues,¡± said
Richard Pazdur, M.D., director of the Office of Hematology and Oncology
Products in the FDA¡¯s Center for Drug Evaluation and Research. ¡°Xofigo is
the second prostate cancer drug approved by the FDA in the past year that
demonstrates an ability to extend the survival of men with metastatic
prostate cancer.¡±

In August 2012, the FDA approved Xtandi to treat men with metastatic
castration-resistant prostate cancer that has spread or recurred, even with
medical or surgical therapy to minimize testosterone. Xtandi is approved
for patients who have previously been treated the chemotherapy drug
docetaxel.

Xofigo¡¯s safety and effectiveness were evaluated in a single clinical
trial of 809 men with symptomatic castration-resistant prostate cancer that
spread to bones but not to other organs. Patients were randomly assigned to
receive Xofigo or a placebo plus best standard of care.

The study was designed to measure overall survival. Results from a
pre-planned interim analysis showed men receiving Xofigo lived a median of
14 months compared to a median of 11.2 months for men receiving placebo. An
exploratory updated analysis conducted later in the trial confirmed
Xofigo¡¯s ability to extend overall survival.

The most common side effects reported during clinical trials in men
receiving Xofigo were nausea, diarrhea, vomiting and swelling of the leg,
ankle or foot. The most common abnormalities detected during blood testing
included low levels of red blood cells (anemia), lymphocytes
(lymphocytopenia), white blood cells (leukopenia), platelets
(thrombocytopenia) and infection-fighting white blood cells (neutropenia).




gandigoBligma from Sweden
Comment 6 of 28, added on October 21st, 2012 at 4:21 AM.
comment

Robert’s Tree:
As Robert sat him against his tree
In fear of the Demiurge, or in mock;
I and my adam creep stealthily
Amid the city of agonized flock,
And barricades seek to avoid;
Warmth of shadows, there in merest void.

The bang around in guns and the dagger
And yellow fear in street corners lurks
While cops in blue stumble and stagger
And the silent kiss of god turns to smokes
And adam’s sweet eyes gaze and smile his lips
On my soft bosom he dreams and slips

Our wings are therefore growing slender
Enough to soar and lift us high above
We’ll fly and watch the shadows thereunder
And teach the demiurge our words of love
And pray him to care of the city
And reap the secrets of Robert’s tree
Altair Laahad(All Rights Reserved)


Altair Laahad
Comment 5 of 28, added on February 29th, 2012 at 5:33 AM.
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an Orthopaedic the wisdom eat.strongMake going some idea of size costs. And
That important and doctor, a big.

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Comment 4 of 28, added on April 13th, 2010 at 1:55 AM.

That is VERY very interesting, Sunil. I would like to find that out too. I
think it does though, or in any way that human expression would, like
music, art, individuality.That would be very interesting to find out.

Emily from United States
Comment 3 of 28, added on April 11th, 2010 at 12:00 AM.
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Comment 2 of 28, added on April 16th, 2005 at 11:21 AM.

Well, first I'd like to say that I'm from India, a poet by inclination and
a journalist by trade for the time being. I believe Robert Frost certainly
had a metaphysical edge to his poetry. I am unaware of the history of
Robert Frost but I have heard his recitation in JFK'S inaugural address.
What I'd like to say is that all poets senses are slightly skewed. This of
course is my personal perception. Why a poet creates is a question that we
should ask? What is it that makes a poet a poet? Well I don't know if
people in the United States identify with this, but what I believe is that
our great president, seer,visionary and poet is also a scientist? So, is
there a connection between poetry and science.? If so, we should also
identify the neural pathways which lead to this. I believe America is in
the forefront of this particular initiative. I would certainly want the
fountainhead of Western civilisation to actually research on why any poet
was creative and whether poetry actually has practical value.

Sunil Kumar from India
Comment 1 of 28, added on January 25th, 2005 at 8:19 PM.

I have two things to comment on. First of all, there are two mistakes.
First Stanza: "i was just as the light was beginning to fail" should be,
"It was just as the light was beginning to fail", and a mistake in Stanza
Three: "I was something among the leaves I sought" should be, "It was
something among the leaves I sought"
The second thing I would like to comment on is that i believe that this
poem has a deeper meaning, like with a number of other poems, that is
hidden between the lines. It is powerful in terms of language usage and the
feeling of how Robert Frost captured what he was thinking!

Michael Summers from United States

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Information about The Demiurge's Laugh

Poet: Robert Frost
Poem: 24. The Demiurge's Laugh
Volume: A Boy's Will
Year: 1913
Added: Feb 1 2004
Viewed: 39465 times
Poem of the Day: Oct 21 2012


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